Hinspiele 18./19. Febr. - Rückspiele 26. Febr.
| Paris St. Germain | - | VfL Wolfsburg |
| FC Kopenhagen | - | Manchester City |
| NEC Nijmegen | - | Hamburger SV |
| Sampdoria Genua | - | Metalist Charkow |
| SC Braga | - | Standard Lüttich |
| Aston Villa | - | ZSKA Moskau |
| Lech Posen | - | Udinese Calcio |
| Olympiakos Piräus | - | AS St. Etienne |
| AC Florenz | - | Ajax Amsterdam |
| Aalborg BK | - | Deportivo La Coruña |
| Werder Bremen | - | AC Mailand |
| Girondins Bordeaux | - | Galatasaray Istanbul |
| Dynamo Kiew | - | FC Valencia |
| Zenit St. Petersburg | - | VfB Stuttgart |
| Olympique Marseille | - | Twente Enschede |
| Schachtjor Donezk | - | Tottenham Hotspur |
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